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Tamsulosin is a more selective α1A subtype antagonist, which maintains the α-antagonist effect on the prostatic capsule and bladder neck but has less of an effect on the vascular system and blood pressure. In fact, tamsulosin is ineffective and not indicated in the treatment of hypertension. Tamsulosin has a favorable side effect profile in regard to problems related to hypotension and dizziness compared to those of terazosin and doxazosin. Clinical trials of 1 year or longer with tamsulosin show high tolerability for the 0.4 mg dose and no significant interaction with other antihypertensive medications- Rev Urol. 2005; 7(Suppl 4): S13–S21.
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