Cylnida- BS
Dual Approach Anti-Hypertensive


Composition : Bisoprolol 5mg + Cilnidipine 10mg

Form : Tablets / Pack : 1 X 10's / Type : AA

Description : Since Cilnidipine inhibits N-type channels thus it inhibits the activation of the sympathetic nervous system hence preferred drug for White Coat Hypertension and morning hypertension (closely associated with sympathetic activity) Cilnidipine has been extensively studied by researchers in its preclinical and clinical development phases. Renoprotective, neuroprotective and cardioprotective effects of Cilnidipine have been demonstrated in clinical practice - Indian Heart J. 2013 Dec; 65(6): 691–695. Bisoprolol is a beta-blocker with high selectivity for beta-1 ARs. It has no intrinsic sympathomimetic activity and no membrane stabilizing activity. Lacking of any ancillary property, it may probably be considered as “the purest” beta-1 AR blocker for the treatment of HF- Ther Clin Risk Manag. 2007 Aug; 3(4): 569–578.

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Cylnida-10
The Fourth Generation CCB


Composition : Cilnidipine 10mg

Form : Tablets / Pack : 10's / Type : ALU-ALU

Description : The study indicates that unlike Amlodipine, Cilnidipine which inhibits L-and N-type calcium channels will be useful for patients with hypertension and cardiovascular disease, diabetes mellitus or renal disease and proves to be a better alternative to existing calcium channel blockers.- Int J Basic Clin Pharmacol. 2013; 2(2): 160-164.

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Cylnida-5
The Fourth generation CCB


Composition : Cilnidipine 5mg

Form : Tablets / Pack : 10's / Type : ALU-ALU

Description : The study indicates that unlike Amlodipine, Cilnidipine which inhibits L-and N-type calcium channels will be useful for patients with hypertension and cardiovascular disease, diabetes mellitus or renal disease and proves to be a better alternative to existing calcium channel blockers.- Int J Basic Clin Pharmacol. 2013; 2(2): 160-164.

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Candosa-8
When Fail To Tolerate Current Drug Therapy


Composition : Candesartan 8mg

Form : Tablets / Pack : 1 X 10’s / Type : Alu Alu

Description : Preliminary evidence suggests that the blood pressure-lowering effects of candesartan are associated with the prevention or improvement of end-organ damage in patients with hypertension. Candesartan improves insulin sensitivity in patients with hypertension and does not affect glucose homeostasis or the serum lipid profile in those with coexisting type 2 (non-insulin-dependent) diabetes mellitus. Candesartan is well tolerated in patients with hypertension. Pooled data indicate that the tolerability profile of the drug is not significantly different from that of placebo, with headache being the most commonly reported event. Candesartan is better tolerated than enalapril, primarily because of a reduced incidence of cough and was not associated with the hypokalaemia or hyperuricaemia seen with hydrochlorothiazide in a study in patients aged > or = 75 years - Drugs. 1998 Nov;56(5):847-69.

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Candosa-4
When Fail To Tolerate Current Drug Therapy


Composition : Candesartan 4mg

Form : Tablets / Pack : 1 X 10’s / Type : Alu Alu

Description : Preliminary evidence suggests that the blood pressure-lowering effects of candesartan are associated with the prevention or improvement of end-organ damage in patients with hypertension. Candesartan improves insulin sensitivity in patients with hypertension and does not affect glucose homeostasis or the serum lipid profile in those with coexisting type 2 (non-insulin-dependent) diabetes mellitus. Candesartan is well tolerated in patients with hypertension. Pooled data indicate that the tolerability profile of the drug is not significantly different from that of placebo, with headache being the most commonly reported event. Candesartan is better tolerated than enalapril, primarily because of a reduced incidence of cough and was not associated with the hypokalaemia or hyperuricaemia seen with hydrochlorothiazide in a study in patients aged > or = 75 years - Drugs. 1998 Nov;56(5):847-69.

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Bampril-5
The First Step to Treat Hypertension


Composition : Benazepril 5mg

Form : Tablets / Pack : 10 x 10's / Type : ALU-ALU

Description : Benazepril is a class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. Benazepril is an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Benazeprilat, is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies and to prevent stroke, myocardial infarction and cardiac death in high-risk patients. Benazepril competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin-I to angiotensin-II. This prevents the potent vasoconstrictive actions of angiotensin-II resulting in vasodilation. Benazepril also decreases angiotensin-II induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

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Granry-D
The Best Way To Control… Diagnose It


Composition : Irbesartan 150mg & Chlorthalidone 12.5mg

Form : Tablets / Pack : 10 x 10's / Type : ALU-ALU

Description : The angiotensin-II–receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes- New England J Med 2001; 345:851-860. There is some evidence that irbesartan provides protective cardiovascular effects beyond its antihypertensive action. This is particularly true for its beneficial effects on slowing the progression of early-stage and late-stage renal disease in hypertensive patients with type 2 diabetes and on promoting regression of left ventricular mass in patients with hypertension and left ventricular hypertrophy. Recent research has further highlighted the positive role of irbesartan in preventing recurrence of arrhythmia in patients with persistent atrial fibrillation, when added to classical antiarrhythmic therapy. Finally, some data suggest an additional benefit in cardiac disease, through a reduction in the risk of heart failure episodes, as observed with other angiotensin receptor blockers- Integr Blood Press Control. 2011; 4: 17–26.

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GRANRY-150
The Best Way To Control… Diagnose It..


Composition : Irbesartan 150mg.

Form : Tablets / Pack : 10 x 10's / Type : ALU-ALU

Description : The angiotensin-II–receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes- New England J Med 2001; 345:851-860. There is some evidence that irbesartan provides protective cardiovascular effects beyond its antihypertensive action. This is particularly true for its beneficial effects on slowing the progression of early-stage and late-stage renal disease in hypertensive patients with type 2 diabetes and on promoting regression of left ventricular mass in patients with hypertension and left ventricular hypertrophy. Recent research has further highlighted the positive role of irbesartan in preventing recurrence of arrhythmia in patients with persistent atrial fibrillation, when added to classical antiarrhythmic therapy. Finally, some data suggest an additional benefit in cardiac disease, through a reduction in the risk of heart failure episodes, as observed with other angiotensin receptor blockers- Integr Blood Press Control. 2011; 4: 17–26.

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Granry-150H
Mild to Moderate Hypertension


Composition : Irbesartan 150mg + Hydrochlorothiazide 12.5mg

Form : Tablets / Pack : 10's / Type : ALU-ALU

Description : Effective therapeutic option in Mild to Moderate hypertension - Drugs ISSN 0012-6667 Coden Drugay. Significantly reduces Mean 24 hrs ADBP & Ambulatory Systolic Blood Pressure & well tolerated - Ren fail 2007;29(7) 843-8 Its safety & Tolerability is Superior to Placebo - Amer, Journal of Card. 23 Feb 1998

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Granry-CL
Re-think on Hypertension Management


Composition : Cilnidipine 5mg + Irbesartan 150mg

Form : Tablets / Pack : 10’s / Type : ALU-ALU

Description : Cilnidipine signficantly decreased the 24 h blood pressure by 6.5 1.7 mm Hg systolic (mean s.e.mean; P>0.01) and 5.0 1.1 mmHg diastolic (P > 0.01), whereas Cilnidipine did not change heart rate or any indices of power spectral components - Br J Clin Pharmacol. Dec 2000; 50(6): 615-620 There was no correlation between the degree of daytime SBP change and that of daytime PR change after amlodipine treatement (r=-0.08, n.s.) but there was a significant negative correlation between the degree of daytime SBP change and that of day-time PR change after cilnidipine treatment (r=-0.27, p<0.05). N-type calcium channel blockade by Cilnidipine may not cause reflex tachycardia, and may be useful for hypertensive treatment - Hypertens Res. 2005 Dec; 28(12): 1003-8

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