Esomeprazole 40mg GR + Levosulpiride 75mg PR
/ Pack :
1 X 10s
/ Type :
The absolute bioavailability is 64% after a single dose of Esomeprazole 40mg and increases to 89% after repeated once daily administration with 97% plasma protein bound. Levosulpiride blocks the enteric dopamine (D2 ) receptors (both neuronal & muscular) and also acts as an agonist at serotonin (5-HT4 ) receptor. Both the above actions increase the release of acetylcholine (Ach). Ach increases GI peristalsis and also increases lower esophageal sphincter pressure thereby preventing reflux of GI contents towards esophagus.
Esomeprazole demonstrates significantly greater efficacy than omeprazole in the treatment of GERD patients with erosive esophagitis. The tolerability and safety of esomeprazole are comparable to that of omeprazole - The American J of Gastroenterology, Vol 96, Iss 3, Mar 2001, P. 656-665
Levosulpiride is an effective and safe drug in the treatment of dysmotility-like functional dyspepsia and non-erosive reflux disease - Ther Clin Risk Manag. 2007 Mar; 3(1): 149–155.
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Esomeprazole 40mg GR Levosulpiride 75mg PR