Benidipine 4mg + Chlothalidone 12.5mg
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Description : Reno-Protection:
-By triple calcium channel blocking activity, dilates Afferent and Efferent arterioles reduces glomerular pressure.
-Prevents the progression of Reno parenchymal hpertension and nephropathy by increasing NO fromation in the renal Parenchyma.
-Exerts Natriuretic effect.
-Benidipine partially inhibits angiotensin II induced upregulation of the mRNAs and shows Ca2 + influx inhibitory activities for aldosterone production.
-Benidipine attenuates the extent of ischemia through NO-dependent mechanism.
-Benidipine reduces left ventricular mass and normalized systemic collagen type degradation abnormalities in essential hypertensive patients with severe LVH.
-Benidipine increases in the plasma levels of CGRP in the patients with essential hypertension.
-Benidipine hydrochloride decreases oxidative stress."
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