Repaglinide 2mg + Metformin 500 mg
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An FDC tablet of repaglinide/metform 2 mg/500 was bioequvalent to individual tablets of repalinide 2 mg and metformin 500 mg. Additionally, an FDC tablet of repeglinide/metformin 2 mg/500 mg Finally, no unexpected safety convern were noted with repaglinide/metformin combination tablet therapy. Our results suggest that FDC tablets of repaglinide and metformin would provide safety and efficacy comparable to that of repaglinide and metformin administered as separate formulations - Clin Drug Investig. 2008; 28(9): 573-82.
Repaglinide Stimulates Release Of Insulin From Pancreatic B-Cells By Inhibiting K Efflux Via Closure Of ATP Regulated K Channels, This Results In Depolarization Of The Cell and Opening of Voltage-Dependent Ca Channels, Which Increases Influx Of Ca Into The Beta Cells And Causes Release of Insulin
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