Sulpraz
The Matchless Duo


Composition : Rabeprazole 20mg + Levo Sulpiride 75mg SR

Form : Tablets / Pack : 10 x 10’s / Type : ALU-ALU

Description : A prospective, open-label, multicenter design in 342 patients with dysmotility-like functional dyspepsia (n=279) and nonerosive reflux disease (n=63), who received levosulpiride 25 mg 3 times daily orally for 4 weeks. Individual symptoms (pain/discomfort, fullness, bloating, early satiety, pyrosis, regurgitation, and nausea/vomiting) and a global symptom score were assessed at 15, 30, and 60 days after starting treatment. Adverse events also were recorded. There were 151 men and 191 women (mean age 38.8 years) who referred dyspeptic symptoms for a mean of 10.2 (10.7) months. A total of 66.4% patients were treated with 75 mg/day levosulpiride and 33.6% with 50 mg/day. At the 15-day visit, a decrease greater than 50% in the global symptom score was observed. The frequency and intensity of individual symptoms showed a statistically significant decrease (p<0.001) at all visits compared with baseline. At the 30-day visit, all symptoms had almost disappeared, a trend that was maintained until the last visit. Treatment with levosulpiride was well tolerated and only 40 adverse events were recorded (galactorrhea 26.7%, somnolence 17.8%, fatigue 11.1%, headache 11.5%) and no patient had to abandon the study due to side effects.
Conclusion: levosulpiride is an effective and safe drug in the treatment of dysmotility-like functional dyspepsia and non-erosive reflux disease- Ther Clin Risk Manag. 2007 March; 3(1): 149–155.
Rabeprazole binds to and inactivates the H+/K+-ATPase of gastric parietal cells, causing inhibition of the proton pump that transports H+ into the gastric lumen, the final common step in gastric acid production. Rabeprazole is a prodrug and is converted to the active form in the acidic secretory canaliculi of parietal cells. Because the inhibition is irreversible, acid secretion is suppressed for 24 to 48 hours, until new proton pump molecules have been synthesized and transported to the cell membrane.

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Montiluk-450
Colonic Acidfier & Stool Softener


Composition : Lactulose 15gm per 10ml solution

Form : Sugar Free solution / Pack : 1 X 450ml / Type : Pet Bottle

Description : Lactulose is being used since the 1950s. It is on the World Health Organization's List of Essential Medicines. Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. Lactulose is also commonly given to elderly people who have diminished mental or physical capacity to have a daily bowel movement. It is the treatment of choice for constipation in rest homes both because of its effectiveness and its lack of side effects. Lactulose has a sweet taste that can be completely masked by mixing it with coffee, tea, fruit juice, produces results within 4 hours if taken on a daily basis. Lactulose is useful for treatment of hemorrhoids because it produces a soft bowel movement. Lactulose is considered a prebiotic because it modulates the beneficial bacterial flora of the gut and is considered a digestive aid. Modulation of gut flora presumably works by reducing potential pathogenic bacteria such as Escherichia coli and Staphylococcus species in stool, with increase in non-urease producing Lactobacillus limiting ammonia production. Moreover, lactulose is converted to lactic and acetic acid which results in acidification of colonic contents. The low pH decreases passive non-ionic diffusion of ammonia thus lowering its systemic concentration. Furthermore, with its prebiotic potential, lactulose also encourages growth of probiotic bacteria such as Bifidobacterium species that are known to have health-promoting effects.

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Montiluk-200
Colonic Acidfier & Stool Softener


Composition : Lactulose 15gm per 10ml solution

Form : Sugar Free solution / Pack : 1 x 200ml / Type : Pet Bottle

Description : Lactulose is being used since the 1950s. It is on the World Health Organization's List of Essential Medicines. Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. Lactulose is also commonly given to elderly people who have diminished mental or physical capacity to have a daily bowel movement. It is the treatment of choice for constipation in rest homes both because of its effectiveness and its lack of side effects. Lactulose has a sweet taste that can be completely masked by mixing it with coffee, tea, fruit juice, produces results within 4 hours if taken on a daily basis. Lactulose is useful for treatment of hemorrhoids because it produces a soft bowel movement. Lactulose is considered a prebiotic because it modulates the beneficial bacterial flora of the gut and is considered a digestive aid. Modulation of gut flora presumably works by reducing potential pathogenic bacteria such as Escherichia coli and Staphylococcus species in stool, with increase in non-urease producing Lactobacillus limiting ammonia production. Moreover, lactulose is converted to lactic and acetic acid which results in acidification of colonic contents. The low pH decreases passive non-ionic diffusion of ammonia thus lowering its systemic concentration. Furthermore, with its prebiotic potential, lactulose also encourages growth of probiotic bacteria such as Bifidobacterium species that are known to have health-promoting effects.

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Citipride
A Superior gastro-prokinetic agent of the benzamide class


Composition : Cinitapride 1mg

Form : Tablets / Pack : 10 x 10's / Type : ALU-ALU

Description : Cinitapride, either given alone or after co-administration with ketoconazole 200 mg b.i.d., had no effect on cardiac repolarization as measured by changes in the heart rate-corrected QT interval on the surface electrocardiogram - Drug Metab Dispos. 2007 Jul;35(7):1149-56.

After 4 weeks of treatment, the Global Index Score showed statistically significant reduction in 58 (48.92%) patients (p<0.01). Similar reduction (p<0.01) was seen in individual dyspepsia symptoms; early satiety, post-prandial fullness, and abdominal distension. The 7 point Likert's scale also showed similar improvement in subjective response (p<0.01).The quality of life also improved significantly at week 2 and 4 (p<0.01). No abnormal results were seen in vital signs, physical and laboratory examination except an unexplained rise in globulin level. Only one adverse event (sore throat) was reported during the study - J Pak Med Assoc. 2013 Jun; 63(6):747-51

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Montiluk-300
Colonic Acidfier & Stool Softener


Composition : Lactulose 15gm per 10ml solution (Sugar Free Osmotic Laxative)

Form : Solution / Pack : 300 ml / Type : Bottle

Description : Controlled studies have shown that Montiluk therapy reduces Blood Ammonia Level by 25-50%. When the laxative effect achieved, Dose may be reduced to recommended daily dose.

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Mucoraz
Controls Heart Burn with very first dose


Composition : Oxetacaine10mg + Al.Hydroxide 0.291gm + Mg.Hydroxide 98mg Orange Flavored

Form : Suspension / Pack : 170 ml / Type : Bottle

Description : Aluminium hydroxide to form a coating over the inflamed gastric mucosa. Magnesium hydroxide to counter-act constipating effects of Aluminium hydroxide. Oxetacaine to exert a prolonged topical anesthetic action.

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Prazocid-DSR
Unsurpassed Acid Control


Composition : Pantoprazole 40mg + Domperodone 30mg SR

Form : Capsules / Pack : 10’s / Type : ALU-ALU

Description : Pantoprazole: During the post-treatment phase, patients have significantly lower risk to relapse GERD. Digestion, 2007;75 Suppl 1:69-78. Epub 2007 May 4. Domparidone: Selective prokeinetic without Diarrhoea and Cardiotoxicity.

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Kinetic-SR
For the Tummy Troubles


Composition : Levo-Sulpiride 75mg Sustained Release

Form : Tablets / Pack : 10's / Type : ALU-ALU

Description : Levo-sulpiride is an effective and safe drug in the treatment of dysmotility-like functional dyspepsia and non-erosive reflux disease - Ther Clin Risk Manag.2007 March; 3(1): 149-155 Levo-sulpiride could be a new solution for pre-mature ejaculation based on DA (Dopamine) therory, that controls human sexual function. Since DA seems to have a role in facilitating sexual arousal and in lowering the ejaculatory threshold, DA antagonists are likely to have inhibitory function. Base on these results, we theorise that this drug could be quite - Int. J. of Impetence Research, Aug 2002, Vol. 14, Nov. 4

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Citipride-SR
When GUT behaves like a python


Composition : Cinitapride 3mg Sustained Release

Form : Tablets / Pack : 10's / Type : ALU-ALU

Description : Cinitapride, either given alone or after co-administration with ketoconazole 200 mg b.i.d., had no effect or cardiac repolarization by changes in the heart rate-corrected QT interval on the surface electrocardiogram. Drug Metab Dispos. 2007 Jul;35(7): 1149-56 The drug was effective in minimizing dyspepsia symptoms and improving the quality of life of patients. It was well tolerated and was almost free of side effects. Pak Med Assoc.2013 Jun ;63(6):747-51

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Dexpraz-DSR
Effective Acidity Control & Dysmotility


Composition : Dexrabeprazole 10mg + Domperidone 30mg SR

Form : Capsules / Pack : 10's / Type : ALU-ALU

Description : Efficacy of Dexrabeprazole 10mg is better than Rebeprazole 20mg with regards to improvements/healing of endoscopic lesions and relief from symptoms of Regurgitation - Dr. Med. J-South Asia Edition 2006;22-112 Safe with no adverse reaction reported - World J Gastroenterol. 2007b; 13(30):4100-2

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